The antioxidation effects of Coicis Semen and Sophorae Radix on the radical scavenging ability from 1,1´-Diphenyl-2-picrylhydrazyl(DPPH), activities of nitrate reductase(NR) and the contents of glutathione(GSH) superoxide dismutase(SOD), catalase, lipid peroxidase(LPO) in rat liver cells were examined.
In in vitro studies, Coicis Semen extract had greater DPPH-radical scavenging ability than Sophorae Radix. The NR activity in the cells was more increased by the treatments of Coicis Semen extracts than Sophorae Radix extract.
In in vivo studies, the acetaminophen-induced inhibitions of SOD, GSH, LPO and catalase activities were significantly recoverd by the treatment of Coicis Semen and Sophorae Radix extracts. The recovery by Coicis Semen extract treatment was similar to the level of ascorbic acid treatment. Therefore, it seems that Coicis Semen extract has similar effects on the antioxidation compared with ascorbic acid, well-known antioxidant.
These results suggest that Coicis Semen seems to have more potent effects on the antioxidation than Sophorae Radix extract.
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